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Who We Are » Jeffrey A. Albrecht, Ph.D.

Dr. Albrecht obtained his Bachelor of Science degree in Microbiology from the University of Illinois Urbana-Champaign in 1989 and his Ph.D. degree in Microbiology and Molecular Genetics from the University of California at Los Angeles (UCLA) in 1996. During his graduate studies and post-doctoral fellowship in the Microbiology and Molecular Genetics department at UCLA, Dr. Albrecht investigated the anaerobic regulation of cytochrome o and cytochrome d oxidase operons in Escherichia coli. Dr. Albrecht joined National Genetics Institute in 1996 as the Director of Research and Development. Under his leadership, National Genetics Institute has developed PCR assays for the detection of melanoma cells in blood and lymph nodes, Human Papiloma virus from cervical swabs, and Epstein-Barr virus in plasma and peripheral blood leukocytes as well as nucleic acid testing assays for West Nile Virus, Simian Virus, and Poliovirus. With his guidance, National Genetics has also refined testing procedures and optimized the sensitivity and efficiency of existing Hepatitis A, B, C and HIV assays.

Publications
The clinical utility of using Catrimox-14-treated whole blood in detecting hepatitis C virus RNA. Patel K, Albrecht J, Owens E, Dev A, Heaton S, Pianko S, Pockros PJ, Conrad A, Blatt LM, and McHutchinson JG. Antivir Ther. 10(4): 535-41, 2005.

A World Health Organization collaborative study to establish a replacement WHO international standard for hepatitis C virus RNA nucleic acid amplification technology assays. Saldanha J, Heath A, Aberham C, Gentili G, Gessner M, Pisani G and The WHO Collaborative Study Group. Vox Sanguinis 88(3): 202-4, April 2005.

A Collaborative study to evaluate a working reagent for West Nile Virus RNA detection by nucleic acid testing. Saldanha J, Heath A, Shead S, Drebot M and The WHO West Nile Virus Collaborative Study Group. Transfusion 45, 97-102, 2005.

Changes in the presence of multiple markers of circulating melanoma cells correlate with clinical outcome in patients with melanoma. Reynolds S, Albrecht J, Shapiro R, Roses D, Harris M, Conrad A, Zeleniuch-Jacquotte A and Bystryn J. Clin Cancer Res. 9(4): 1497-1502, 2003.

Induction of IL-1Ra in resistant and responsive hepatitis C patients following treatment with IFN-con1. Cotler S, Craft T, Ferris M, Morrisey M, McCone J, Reddy R, Conrad A, Jenson D, Albrecht J and Taylor M. J Interferon Cytokine Res. 22(5): 549-54, 2002.

An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon. Cotler S, Reddy R, McCone J, Wolfe D, Liu A, Craft T, Ferris M, Conrad A, Albrecht J, Morrisey M, Ganger D, Rosenblate H, Blatt L. Jenson D and Taylor M. J Interferon Cytokine Res. 21(12): 1011-1019,2 002.

Oxygen- and nitrate-dependent regulation of dmsABC operon expression in Escherichia coli: sites for Fnr and NarL protein interactions. Bearson S, Albrecht J and Gunsalus RP. BMC Microbiol. 2: 13-23, 2002.

Establishment of the first World Health Organization international standard for human parvovirus B19 DNA nucleic acid amplification techniques. Saldanha J, Lelie N, Yu MW, Heath A and The WHO Collaborative Study Group. Vox Sanguinis 82, 24-31, 2002.

An international collaborative study to establish a World Health Organization international standard for hepatitis B virus DNA nucleic acid amplification techniques. Saldanha J, Gerlich W, Lelie N, Dawson P, Heermann K, Heath A and The WHO Collaborative Study Group. Vox Sanguinis 80, 63-71, 2001.

Decrease in circulating tumor cells as an early marker of therapy effectiveness. Bystryn J, Albrecht J, Reynolds S, Rivas M, Oratz R, Shapiro R, Roses D, Harris M and Conrad A. Recent Results Cancer Res. 158:204-207, 2001.

Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of nonsentinel nodes following completion lymphadenectomy for melanoma. Wrightson W, Wong S, Edwards M, Chao C, Conrad A, Albrecht J, Viar V and McMasters K. J Surg Res. 1: 98(1): 47-51, 2001.

Oxygen regulation of the Escherichia coli cytochrome d oxidase (cydAB) operon: roles of multiple promoters and the Fnr-1 and Fnr-2 binding sites. Govantes F, Albrecht J and Gunsalus RP. Mol. Microbiol. 37(6): 1456-1469, 2000.

Aerobic regulation of cytochrome d oxidase (cydAB) operon expression in Escherichia coli: roles of Fnr and ArcA in repression and activation. Cotter PA, Melville SB, Albrecht J and Gunsalus RP. Mol. Microbiol. 25(3): 605-615, 1997.

Effect of microaerophilic cell growth conditions on expression of aerobic (cyoABCDE and cydAB) and anaerobic (narGHJI, frdABCD, and dmsABC) respiratory pathway genes in Escherichia coli. Tseng CP, Albrecht J and Gunsalus RP. J.Bacteriol. 178:1094-1098, 1996.

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